التأثيرات النسيجية والمناعية لبعض الاعضاء في ذكور الجرذان المختبرية العاملة بعقار Paclitaxel
| dc.contributor.author | زهراء يسر حمود | |
| dc.contributor.editor | أ.م.د علاء ريسان رشاد | |
| dc.date.accessioned | 2025-08-03T07:31:30Z | |
| dc.date.available | 2025-08-03T07:31:30Z | |
| dc.date.issued | 2025-04-26 | |
| dc.description.abstract | The current study was designed to investigate the effects of the anticancer drug Paclitaxel on both histological and immunological aspects in laboratory rats (Rattus norvegicus). The rats were divided into three groups, each .comprising 12 rats The results of the study indicated a significant decrease at a probability level of P≤0.05 in hematological parameters, including white blood cell count, and the percentage of lymphocytes, neutrophils, eosinophils, and basophils in rats .treated with Paclitaxel at doses of 2 mg/kg and 4 mg/kg Furthermore, a significant reduction was observed in the red blood cell count at the same probability level (P≤0.05), with the higher dose (4 mg/kg) showing a more pronounced effect compared to the lower dose (2 mg/kg) Histological examination of tissue sections revealed pathological changes in the liver, kidneys, and lungs of the treated rats. Liver tissue sections showed degeneration and necrosis of hepatocytes, inflammatory cell infiltration, edema around the central hepatic vein, vascular congestion, and irregularities .in hepatic cells The kidney tissue sections displayed clear histological changes, including hemorrhagic congestion in blood vessels, bleeding, necrosis, and congestion in .the glomerular capillaries Lung tissue sections exhibited notable changes, including inflammation, tissue damage, necrosis, and degeneration, as well as inflammation in the connective .tissue surrounding the blood vessels Laboratory analyses using ELISA showed that the low-dose group had a significant increase (P≤0.05) in IL-8 levels, while the high-dose group .exhibited a significant decrease (P≤0.05) in serum interleukin-8 level | |
| dc.identifier.uri | https://dspace.utq.edu.iq/handle/123456789/1034 | |
| dc.title | التأثيرات النسيجية والمناعية لبعض الاعضاء في ذكور الجرذان المختبرية العاملة بعقار Paclitaxel | |
| dc.title.alternative | Histological and Immunological Effect of Some Organs in male Rat Treated with Paclitaxel Drugs | |
| dc.type | text::thesis::master thesis | |
| oairecerif.author.affiliation | كلية التربية للعلوم الصرفة / ماجستير علوم حياة | |
| oairecerif.editor.affiliation | جامعة ذي قار / كلية التربية للعلوم الصرفة / قسم علوم الحياة |