Evaluation of Immunological and Non-Invasive Diagnostic Tests for Patients with Suspected H. pylori in Thi-Qar Province
| dc.contributor.author | حسين عبدالحسن عويد | |
| dc.contributor.editor | أ.د. سعد عبدالعزيز عطية, أ.م.د. فائز خلف عبدالمحسن | |
| dc.date.accessioned | 2024-10-28T09:00:34Z | |
| dc.date.available | 2024-10-28T09:00:34Z | |
| dc.date.issued | 2024-09-26 | |
| dc.description.abstract | This Study was conducted on patients with suspected H. pylori and some demographic parameters. The case group was included 120 patients who were consisting 37 males and 83 females. Also control group was included 60 the apparently healthy persons who were consisting of 43 males and 17 females. The study aimed to evaluation of the diagnostic methods for detection of Helicobacter pylori and the relationship of bacteria to some demographic and hematological parameters and study the effect of H. pylori on the Interlukin 32, Interlukin 39 and CXCL9 and their levels in patients with gastric disorders. Started with analyzing blood samples for compelet blood count. Also all patients were conducted to noninvasive test H. pylori Antibody, H. pylori Antigen and Urea breath test, while stool samples culture on Colombia blood agar.The petri dishes inoculated with stool samples were then incubated within jar in condition were 5% O2 and 10% Co2, for five to ten days at 37C°. This study, which of based on the demographical and clinical characteristics of patients, showed that the highest percentage of patients were female (69.17%) and that the most affected age group was the second age group (34. 17%).This study also found that 70.83% of patients were living in urban areas, and the most affected group were females’ housewives (36.67%). According to results, it was noted also that 80% of patients were not suffered from chronic diseases. Finally, this study also results showed that 84.17% of patients had no family history of gastric disorders. This study related to H. pylori tests showed that there was no statistically significant difference between the results of the antibody test, the antigen test, and the urea breath test in patients with gastric disorders, as reported the positive rate was 58.33% and 59.17%, respectively. On the other hand, the study showed a statistical significant difference between types ofgastric disorders. According to the incidence of H. pylori infection was 45.0% and previous infection was 37.50%. Whilest the study results of H. pylori tests based on different tests showed that 39.16% of patients were positive for all tests, while 22.5% of them were negative. Also, 14.17% were positive only for the H. pylori antibody test, and 15.83% were positive for both the antibody test and the breath test. In regareds to results of the serological tests, there was no statistically significant difference was observed between the results of different tests and the sex of the patients. However, the study results found that patients with a family history of gastric disorders had a higher positivity rate (78.95%) for the H. pylori antibody test. The study also showed that patients in urban areas had a higher positivity rates for different tests compared to those in rural areas. However, the situation was different with the other laboratory analyses, as the results of this study showed a statistical significant increase in the number of white blood cells and the percentage of granulocytes in the patients compared to control group, while the percentage of lymphocytes was significantly decrease. A significant increase in mean platelet volume (MPV) and platelet count (PCT) was also observed in the patient group. In addition, concentrations of each immune medaitors (IL-39, IL-32, and CXCL9) were increased significantly in the patient. With statistically significant differences between the patients and the control group in relation on to the demographical and clinical characteristics of patients with gastric disorders. The study also found a difference in the results of diagnostic tests for H. pylori and their relationship to types of gastric disorders. It was also found that there are factors associated with the results of these tests, such as family history and differences in geographical regions. | |
| dc.identifier.uri | https://dspace.utq.edu.iq/handle/123456789/135 | |
| dc.language.iso | en | |
| dc.title | Evaluation of Immunological and Non-Invasive Diagnostic Tests for Patients with Suspected H. pylori in Thi-Qar Province | |
| dc.title.alternative | تقييم المناعة والاختبارات الغير غازية للمرضى المتوقع اصابتهم بجرثومة المعدة في محافظة ذي قار | |
| dc.type | text::thesis::master thesis | |
| oairecerif.author.affiliation | كلية الطب - فرع المختبرات الطبية | |
| oairecerif.editor.affiliation | جامعة ذي قار - كلية الطب |