Detection of carpenems and cefepime activity and assessment class A Carbapenemases genes of Klebsiella pneumoniae isolated from the wounds infections
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2024-09-25
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Despite recent developments in sterilization techniques surgical site infections (SSIs) remain a cause of morbidity and mortality in poor countries. Therefore the present study presented the antibiotic resistance of Klebsiella pneumoniae bacteria isolated from wound infections which produce Carbapenemases alone and synergistically. Three hundred samples were collected from wound patients such as diabetic foot patients and general surgeries from Al-Hussein Teaching, Nasiriya Teaching and Al-Haboubi Teaching Hospitals in Thi Qar Governorate for the period from September - December 2023. All sample were culture on MacConkey and blood agar then identified b morphology methods (culture character, Gram stain, biochemical test, API 20 E).The results showed 90% presence of sixteen bacterial isolates of K. pneumoniae Statistical and descriptive analysis was performed using Chi-square and the rates of susceptibility to resistance varied through the use of four types of carpenems and one type of cephalosporin. Testing for antibiotic susceptibility was done using Kirby-Bauer disc diffusion.The rate of susceptibility to resistance to meropenem was lower (37.5%) While the rate of synergistic resistance was lower to meropenem with Imipenem, Doripenem, and cefepime (43.7%) the exception of Ertapenem the resistance rate was higher (43.7%) in combination with meropenem .As for Imipenem the rate of susceptibility to resistance was lower (43.7%) Synergistically the resistance rate was lower for Imipenem while synergistically the resistance rate was lower for cefepime, Ertapenem and Doripenem (29.4%), (31.2%), (37.5%). While resistance to Ertapenem was higher than Doripenem (56.3%) and (43.8%) synergistically the resistance rate was lower for Ertapenem with Doripenem (31.2%). While the rate of resistance to susceptibility to cefepime was higher was