علاقة الهوموسيستين ببعض المتغيرات البيوكيميائية في مرضى ارتفاع ضغط الدم في محافظة ذي قار
| dc.contributor.author | مروى حميد حسين | |
| dc.contributor.editor | أ.د. محمد عجة عودة | |
| dc.date.accessioned | 2025-03-03T08:14:01Z | |
| dc.date.available | 2025-03-03T08:14:01Z | |
| dc.date.issued | 2022-11-01 | |
| dc.description.abstract | Hypertension is a complex disorder which involves several organ systems and is the primary modifiable risk factor for heart disease. Hypertension is often termed the ―silent killer‖ since many people with high blood pressure (BP) do not know they have the disease until it has progressed. Uncontrolled high BP leads to numerous complications including, but not limited to, heart attack, stroke, aneurysm, heart failure, renal failure. Hyperhomocysteinemia has been associated with an increased risk of atherosclerosis and other cardiovascular diseases. The present study was designed to patients with hypertension in Thi-Qar province, Iraq. This study was aimed to show the relationship between homocysteine levels and NLR with some parameters, in causing high blood pressure. The samples included 70 patients(men 40 and 30 women), where systolic blood pressure(140-160) and diastolic blood pressure(90-100), that were attending at Al- Nasiryiah Teaching hospital during the period between (December, 2021) to (May, 2022) , with70 healthy (men and women ) as a control group. The patients group are divided according to their gender in to two groups men and women and then divided according to their age in to three groups. The measured parameters were studied on the basis of three variables: general comparison, Age, and sex. The results indicate a significant increase in the concentration of serum (Homocysteine Aldosterone, Creatinine and NLR) in patient group in comparison with control group (p>0.05). And a significant decrease in the level of serum vitamin B6 and Folic acid in patient group. Concerning to the changes in lipid profile the results in this study showed a significant increase (p>0.05) in the concentration of cholesterol (TC), triglycerides (TG) , low density lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) compared with the control group, but the high density lipoprotein cholesterol (HDL-C) showed a significant decrease (p>0.05) compared to the control group. The results showed negative correlation between Hcy and (B6, Folic acid , HDL) The results showed positive correlation between Hcy and (NLR ,Aldosterone, Creatinine,TC,TG,LDL,VLDL) The study indicated increase of Homocysteine levels in hypertension patients Therefore, it is considered as a risk factor in hypertension patients.A significant change of Immune cells by Neutrophil to lymphocyte ratio in patients with hypertension.A significant change of more lipid profile parameters in patients with hypertension.Low vitamin B6 and folic acid contributed to an increase in homocysteine by Negative relationship between homocysteine and B vitamins (B6 and folic acid) were found.An increase in Aldosterone Hormone and creatinine levels in hypertension patients, There is positive relationship between homocysteine, Aldosterone and creatinine. | |
| dc.identifier.uri | https://dspace.utq.edu.iq/handle/123456789/919 | |
| dc.title | علاقة الهوموسيستين ببعض المتغيرات البيوكيميائية في مرضى ارتفاع ضغط الدم في محافظة ذي قار | |
| dc.title.alternative | The relationship of Homocystein and some Biochemical parameters in hypertensive Patients from Thi-Qar Governorate | |
| dc.type | text::thesis::master thesis | |
| oairecerif.author.affiliation | كلية العلوم - قسم الكيمياء | |
| oairecerif.editor.affiliation | جامعة ذي قار - كلية العلوم - قسم الكيمياء |